Biostatistics & Epidemiology

Faculty Profile

  • Emily Barrett, PhD

  • Associate Professor

  • Department of Biostatistics and Epidemiology

  • CV

Keywords
Pregnancy; hormones; environmental chemicals; endocrine disruptors; stress; developmental origins of health and disease; perinatal epidemiology; sex differences; fertility.

Biography
Dr. Emily Barrett holds an AB in Biology and English from Amherst College and a PhD in Biological Anthropology from Harvard University. She completed post-doctoral fellowships at the University of California-Los Angeles and Cedars-Sinai Medical Center. As a junior faculty member, she was a scholar in the National Institutes of Health Office of Research on Women's Health's BIRCWH (K12) program.

Research Interests
Dr. Barrett studies the early origins of health and disease, or how exposures early in life shape our subsequent health and developmental trajectories. Because gestation is a particularly sensitive period when body systems are first forming, insults or exposures during this period may have profound downstream effects. Much of Dr. Barrett’s research focuses on prenatal exposure to endocrine disruptors, agents which interfere with the normal activity of hormones in the body. Phthalates are a class of endocrine disrupting chemicals that are found widely in food and consumer products. Nearly 100% of Americans have measurable levels of phthalate metabolites in their bodies, yet our current understanding of how these chemicals affect our bodies is limited. In The Infant Development and the Environment Study (TIDES), Dr. Barrett and colleagues are studying how prenatal exposure to these chemicals impacts reproductive and neurodevelopment, and whether the effects may differ in boys and girls. Other exposures, such as psychosocial stress, disrupt early development as well. Numerous studies have examined how stress during pregnancy may alter cortisol activity and “program” neurodevelopmental, metabolic, and immune outcomes. Much less is known about the extent to which prenatal stress (and related constructs, like anxiety) may also act through other pathways and mechanisms to affect the fetus. For example, evidence from animal models and humans suggests that prenatal stress may alter in utero androgen activity, thereby affecting sex-dependent development in the offspring. Dr. Barrett and collaborators are exploring this hypothesis in the Understanding Prenatal Signals and Infant Development (UPSIDE) Study, with an eye towards better understanding the early origins of sex differences. Concurrent work in this cohort will examine how maternal inflammation during pregnancy contributes to infant and child development. One of the major themes of this research is understanding the role of the placenta in communicating messages about stressors from mother to fetus (and vice versa).

Research Highlights

Assessment of exposure to endocrine disrupting chemicals during pregnancy in relation to reproductive development, neurodevelopment, and growth in childhood;

Examination of maternal stress in relation to sex differences in the offspring;

Investigation of novel biomarkers of the prenatal hormonal milieu in humans;

Exploration of placental morphology and function in relation to prenatal exposures and postnatal outcomes; and

Identification of factors contributing to reproductive health and ovarian function in fertile and infertile women.

Select Publications
ES Barrett,S Sathyanarayana,O Mbowe,SW Thurston,JB Redmon,RHN Nguyen,SH Swan (2017) "First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.", Environmental Health Perspectives 125(5) 077008- http://www.ncbi.nlm.nih.gov/pubmed/?term=28728138&report=abstract

SM Eick,ES Barrett,TJ van 't Erve,RHN Nguyen,NR Bush,G Milne,SH Swan,KK Ferguson (2018) "Association between prenatal psychological stress and oxidative stress during pregnancy.", Paediatric and Perinatal Epidemiology 32(5) 318-326 http://www.ncbi.nlm.nih.gov/pubmed/?term=29603338&report=abstract

CG Bornehag,C Lindh,A Reichenberg,S Wikström,M Unenge Hallerback,SF Evans,S Sathyanarayana,ES Barrett,RHN Nguyen,NR Bush,SH Swan (2018) "Association of Prenatal Phthalate Exposure With Language Development in Early Childhood.", JAMA Pediatrics 172(5) 1169-1176 http://www.ncbi.nlm.nih.gov/pubmed/?term=30383084&report=abstract

ES Barrett,W Vitek,O Mbowe,SW Thurston,RS Legro,R Alvero,V Baker,GW Bates,P Casson,C Coutifaris,E Eisenberg,K Hansen,S Krawetz,R Robinson,M Rosen,R Usadi,H Zhang,N Santoro,M Diamond (2018) "Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility.", Human Reproduction 33(5) 1757-1766 http://www.ncbi.nlm.nih.gov/pubmed/?term=30085177&report=abstract

Scholarly Activities
Grant Proposal Reviewer, National Institutes of Health

Editorial Board, The Journal Hormones and Behavior

Editorial Board, The Journal Fertility and Sterility

Associate Editor, Human Reproduction